Well, the potions do weigh something, but home-made potions are usually lighter than bought ones - something like 0.3 of a pound rather than 0.5. So if you know you're going out dragon stomping (a big part of Skyrim) it's worth stocking up beforehand with health, magicka and stamina potions. I usually sell anything else as being not worth the hassle of carrying round.
The worst that can happen to make you vulnerable is to be suddenly disarmed - when you're facing a boss undead with no sword, that's a heart-stopping moment for the player, let alone the character.
It's why I choose to have a spell in one hand and a sword in the other, forget the two handed weapon options, they're just not worth the risk.
The other thing I've noticed about walkthroughs is that they're all about the single expensive artifact guarded by the frost trolls of doom, but there are all these books lying about and they weigh very little and can each be sold for a small sum of useful gp. Likewise your dead enemies armour, once it gets beyond the hide or fur level, which aren't worth the carrying.
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The worst that can happen to make you vulnerable is to be suddenly disarmed - when you're facing a boss undead with no sword, that's a heart-stopping moment for the player, let alone the character.
It's why I choose to have a spell in one hand and a sword in the other, forget the two handed weapon options, they're just not worth the risk.
The other thing I've noticed about walkthroughs is that they're all about the single expensive artifact guarded by the frost trolls of doom, but there are all these books lying about and they weigh very little and can each be sold for a small sum of useful gp. Likewise your dead enemies armour, once it gets beyond the hide or fur level, which aren't worth the carrying.